Wednesday, July 17, 2013
Memory transference in organ transplant recipients
Friday, March 18, 2011
Lung recipient developed her donor’s allergy
Tom Blackwell, National Post
For a 47-year-old woman with dangerously scarred lung tissue, the double-lung transplant she underwent a couple of years ago was a life saver. It came, though, with an unwelcome bonus.
In the months after her surgery, the Toronto patient suffered four anaphylactic attacks, according to her doctors’ 2009 study of the case. Physicians were stumped by the mysterious affliction in a woman who had never experienced serious allergies before. Then they discovered that the 12-year-old boy whose lungs she received had himself suffered from an acute peanut sensitivity, while the woman’s anaphylactic shock had occurred after she ate foods that likely contained nut traces.
It appeared the young donor’s allergy had been passed on along with his organs.
“When it’s transplanted, everything in the organ is transplanted,” said Dr. Susan Tarlo, a University of Toronto asthma and allergy expert who treated the woman.
Now a string of such unusual cases has prompted medical experts to make plans to start screening potential organ and stem-cell donors for serious allergies - a piece of medical background they had never paid much heed to before.
Draft guidelines prepared at the request of Health Canada call for doctors to ask whether organ donors had a history of anaphylactic shock triggered by allergens like peanuts and shellfish, and whether cell donors have any kind of allergy.
In fact, the organs in such cases often become available when the donors die themselves from allergy-caused shock.
“The transplant recipient may be unaware of the risk for potentially life-threatening hypersensitivity reactions,” says a Health Canada document urging the change in protocol.
The guidelines being developed by expert committees of the Canadian Standards Association say allergic donors should not necessarily be excluded, but that doctors can suggest, at least, that recipients get allergy testing and, if necessary, make lifestyle changes to avoid specific allergens.
Doctors say the “intriguing” problem is described in the medical literature relatively rarely, though Health Canada has suggested it is likely under-reported.
There are reports, nonetheless, of transplant recipients developing allergies to various nuts, seafood, eggs, beans, bananas and avocado, as well as drugs like penicillin, substances like latex, plus dust mites and pet dander, according to Health Canada’s proposal to the CSA for new standards. The allergy can persist for at least 14 years, and symptoms have developed as early as eight days after the transplant.
In one case reported in 2008, a 42-year-old, allergy-free Detroit woman received two donor lungs from someone who had died of anaphylactic shock after eating peanuts. “Seven months later, she ate a peanut-butter cookie at a transplant support group meeting,” they recounted. “Immediately thereafter, she developed an anaphylactic reaction, but survived with prompt treatment.”
There is evidence that the process can work in reverse, as well. In one case, a young patient’s serious peanut allergy disappeared after a bone-marrow transplant from an allergy-free donor. Others have ceased being asthmatic.
Allergies occur when people develop so-called immunoglobulin E antibodies to the particular food or other substance, causing the body’s immune system to react against the allergen. Experts say it is likely that those antibodies are implanted in the transplant recipient, either on their own or on the surface of Mast cells, which release the histamine and other chemicals that contribute to the allergic reaction.
Dr. Tarlo reported on the case of the 47-year-old lung-transplant recipient, who eventually tested strongly positive for peanut allergy herself, according to the physician’s presentation to an American College of Chest Physicians conference. It was likely the cereal, coconut cream pie and chocolate she ate just before the reactions were contaminated with peanut, Dr. Tarlo and colleagues said.
The woman’s test results for peanut allergy gradually disappeared, likely because the transplanted cells carrying the antibodies had died, she said.
The CSA standards, which hospitals implement voluntarily, are likely to be published early in 2012, said Anthony Toderian, a spokesman for the non-profit organization.
For other Canadian provinces click here
Tuesday, December 22, 2009
Transplant memories revisited
The joy of a heart's desire - why organ donation is a wonderful gesture
By Richard Noone: The Daily Telegraph - Australia
IT seemed too real to be mere coincidence - and it brought joy to Kaden Delaney's family.
Kaden's parents Greg and Shelley spent two years finding David Waters, whose life was saved when he received their son's heart after he died in a car crash. But in an exchange of emails they learned Mr Waters amazingly had developed a taste for Burger Rings - which was Kaden's favorite snack treat.
The Delaney's second eldest son was left brain dead after rolling his brother's car into an embankment near their home in Orange, in the state's Central West, in April 2006. In line with his wishes, they donated the 17-year-old's heart, lungs, liver, pancreas and kidneys.
Two years and countless key internet word searches later Mrs Delaney tracked down Mr Waters, the recipient of Kaden's heart.
The 24-year-old from Adelaide suffered a stiffening of the heart ventricles and had months to live.
When they began email contact Mr Waters asked: "Did Kaden like Burger Rings? That's all I seemed to want to eat after my surgery."
Mrs Delaney responded: "I have been informed by a reliable source - Talby, (Kaden's brother) that Kaden loved Burger Rings."
Mr Waters replied: "I certainly think I have got some traits from him, Burger Rings right after the op, I never used to eat them before."
The theory the brain is not the only organ to store memories or personality traits and memory as a process can form in other parts of the body such as the heart has been coined "cellular memory".
The most famous reported case was American Claire Sylvia, a heart-lung transplant recipient, who documented her sudden craving for beer, chicken nuggets and green peppers in a best-selling memoir after discovering her donor was an 18-year-old male who died in a motorcycle accident.
Westmead Millennium Institute professor and president of the International Transplantation Society Jeremy Chapman said the phenomenon had not been proven.
"There is no scientific basis of such a claim," he said. "There's so much fiction around transplants."
“You Have the Power to Save Lives – Register to be an organ and tissue donor & Tell Your Loved Ones of Your Decision”
Register to be a donor in Ontario or Download Donor Cards from Trillium Gift of Life Network. NEW for Ontario: recycleMe.org - Learn The Ins & Outs Of Organ And Tissue Donation. Register Today! For other Canadian provinces click here
In the United States, be sure to find out how to register in your state at ShareYourLife.org or Download Donor Cards from OrganDonor.Gov
In Great Britain, register at NHS Organ Donor Register
In Australia, register at Australian Organ Donor Register
Your generosity can save up to eight lives with heart, kidneys, liver, lungs, pancreas and small intestine transplants. One tissue donor can help up to 100 other people by donating skin, corneas, bone, tendon, ligaments and heart valves
Has your life been saved by an organ transplant? "Pay it forward" and help spread the word about the need for organ donation - In the U.S. another person is added to the national transplant waiting list every 11 minutes and 18 people die each day waiting for an organ or tissue transplant.
Monday, November 09, 2009
Transplant Memories - Fact or Fiction?
This is another post on the topic and there have been many other such stories in the past. I can remember reading about a heart recipient, a construction worker, who started to listen to classical music and buy classical albums which he had no liking for previously. It turned out that he received the heart of a musician that was hit by a car on his way to play in a symphony orchestra.

Epoch Times
Legend has it that about 2,500 years ago, during China’s Warring State Period, two men went to see a great doctor by the name of Bian Que. Bian cured their sickness very quickly but discovered that they had another problem that had been growing more serious over time. Bian said that they would both get well if they exchanged their hearts, and they agreed to let Bian perform the surgery.
Bian had the two men drink some anesthetics and they lost consciousness for three days, during which Bian opened their chests, exchanged their hearts, and applied medicine. When they regained consciousness, they had already recovered and were as well as before.
But something was wrong: When they returned home, they were both baffled because their wives couldn’t recognize them. It turned out that they had both gone to the other person's home and thought that the other person’s wife was their wife.
It seems inconceivable that such a surgery could have been performed 2,500 years ago, but this story is unbelievably similar to the situation observed in some modern heart transplant cases.
The U.K.’s Daily Mail reported that, after a heart transplant, Sonny Graham of Georgia fell in love with his donor’s wife and married her. Twelve years after their marriage, he committed suicide the same way his donor did.
In another Daily Mail report, a man named William Sheridan received a heart from an artist who died in a car accident, and suddenly he was able to produce beautiful drawings of wildlife and landscapes.
Claire Sylvia, the recipient of a heart and a lung in 1988, wrote in her book A Change of Heart: A Memoir that after the transplant she started to like beer, fried chicken, and green pepper—all of which she didn’t like before but her donor, an 18-year-old boy, liked.
She had a dream in which she kissed a boy she thought to be named Tim L., and inhaled him into her during the kissing. She later found that Tim L. was the name of her donor. She wondered if it was because one of the doctors mentioned the name during her surgery, but was told that the doctors did not know the name of the donor.
In a paper published in the Journal of Near-Death Studies, Dr. Paul Pearsall of the University of Hawaii and Dr. Gary Schwartz and Dr. Linda Russek of the University of Arizona discussed 10 cases of heart or heart-lung transplants in which the recipients were reported to have “changes in food, music, art, sexual, recreational, and career preferences, as well as specific instances of perceptions of names and sensory experiences related to the donors.”
In one of the cases that they described, the donor was an African American, so the recipient thought the donor would like rap music and therefore didn’t think the transplant was the cause of his new preference for classical music. However, it was found that the donor was a violin player and loved classical music.
This case suggests that changes in organ recipients’ preferences occur without the recipients anticipating them. Thus these cases are unlike the placebo effect, in which patients’ health conditions change in the direction of their expectations.
In addition, the researchers pointed out that like the above recipients, there might be other recipients who dismiss the idea that they adopted their donors’ preferences because of their expectations of the donors, so the number of organ transplant recipients who experienced a personality change similar to that of their donors might be underrepresented.
Pearsall, Schwartz, and Russek concluded that it is unlikely these cases happened out of coincidence, and hypothesized that it is because of cellular memory, meaning that memories and preferences can be stored in cells. However, it is currently unknown whether this form of memory exists.
To see their report, please visit http://www.littleurl.net/ac45f9

“You Have the Power to Save Lives – Sign Your Donor Card & Tell Your Loved Ones of Your Decision”
Register to be a donor in Ontario or Download Donor Cards from Trillium Gift of Life Network. NEW for Ontario: recycleMe.org - Learn The Ins & Outs Of Organ And Tissue Donation. Register Today! For other Canadian provinces click here
In the United States, be sure to find out how to register in your state at ShareYourLife.org or Download Donor Cards from OrganDonor.Gov
In Great Britain, register at NHS Organ Donor Register
In Australia, register at Australian Organ Donor Register
Your generosity can save up to eight lives with heart, kidneys, liver, lungs, pancreas and small intestine transplants. One tissue donor can help up to 100 other people by donating skin, corneas, bone, tendon, ligaments and heart valves
Has your life been saved by an organ transplant? "Pay it forward" and help spread the word about the need for organ donation - In the U.S. another person is added to the national transplant waiting list every 11 minutes and 18 people die each day waiting for an organ or tissue transplant.