(HealthDay News) -- Compared to kidney transplantation alone, a simultaneous kidney-pancreas transplant improves the likelihood of long-term survival in patients with type 1 diabetes and end-stage renal disease (ESRD), according to a German study.
The researchers analyzed the long-term outcomes of more than 11,000 patients with type 1 diabetes and ESRD who had a kidney transplant between 1984 and 2000, including 3,500 who had simultaneous kidney-pancreas transplantation. In some cases, patient and transplanted kidney survival were evaluated up to 18 years after the transplant.
After adjusting for other factors, the researchers concluded that patients who received simultaneous kidney-pancreas transplants had better long-term survival. Beyond 10 years, the risk of death in the kidney-pancreas group was 45 percent lower than in the kidney group.
That improved long-term survival was largely the result of a lower risk of cardiovascular disease -- 37 percent among kidney-pancreas patients compared with 46 percent to 49 percent in kidney-only patients.
"Based on these results, we feel that all type 1 diabetics with kidney failure should be considered for simultaneous pancreas-kidney transplantation," Dr. Christian Morath, of the University of Heidelberg, said in a prepared statement.
The study appears in the August issue of theJournal of the American Society of Nephrology.
"Our study shows that a functioning pancreas has a benefit for the simultaneously transplanted kidney," Morath said. "At the same time, this procedure prolongs the survival of the patient, compared to a patient who received only a kidney transplant."
Morath said the lower risk of cardiovascular death among kidney-pancreas transplant patients "is most likely due to the [normal blood sugar levels] in patients who received a combined treatment."
The results "show an interaction of different and independent organs -- kidney, pancreas, and heart -- with respect to survival of the patient."
More information
The National Kidney Foundation has more about kidney transplantation.
SOURCE: American Society of Nephrology, news release, May 21, 2008
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2 comments:
with the exceptions of the Heart and Liver, all other forms of organ transplant should be considered elective surgery. The deteriorating effects of the antirejection meds for my KP transplant have left me a shell of my former self. I was far better-off as full-time diabetic on dialysis,than I am now. I wouldn't wish this on anyone.
anonymous is so wrong. im sorry you are not feeling well on your drugs. but my kp transplant have given me live. dialysis is not life diabetes and its never ending complications was not life. i was dying. now im living. the side effects are part of life. trust me they are not even close to how bad it would have got on long term dialysis. i worked there and watched people deteriroate. each person reacts different but dont judge what one should get because you dont like your drugs. i bless the bad days to because my organs work 10years strong im alive, i should have benn dead 10 years ago. if it was elective i would be
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