Friday, January 13, 2006

New hope for idiopathic pulmonary fibrosis patients?

When I was diagnosed with idiopathic pulmonary fibrosis in the fall of 1999 there was no hope for slowing or stopping the progression of the disease. The only option was a lung transplant.

The following news release describes a University of Pittsburgh study that suggests standard anti-inflammatory therapy may not be appropriate for many interstitial lung disease patients such as those with idiopathic pulmonary fibrosis (IPF) and a related study suggests that a protein known as osteopontin may be a target for therapy.

The investigators suggest that if their findings hold up in further, larger studies, doctors may be able to slow or stop the progression of this deadly disease. This is probably a long way from reality but at least there's a glimmer of hope for the future.

PITTSBURGH, Jan. 11, 2006 – In an article in the Jan. 15 issue of the American Journal of Respiratory Critical Care Medicine, University of Pittsburgh researchers report that a serious, life-threatening form of pulmonary fibrosis, called idiopathic pulmonary fibrosis, lacks all the hallmarks of inflammation and is probably unnecessarily treated with anti-inflammatory drugs. Moreover, in a related study, (see below) the investigators identified a protein found in excess amounts in the lung tissue of patients with idiopathic pulmonary fibrosis, which may be a more appropriate target for therapy.

Interstitial lung disease describes a diverse set of chronic lung conditions that often have strikingly similar symptoms but different clinical courses. However, all are characterized by differing degrees of progressive scarring of lung tissue between the air sacs, or the interstitium. With repeated damage, the interstitium becomes thickened and stiff, or fibrotic, making it increasingly difficult for the individual to breathe. Some forms of interstitial lung disease, particularly idiopathic pulmonary fibrosis, which has no known cause, have a very high death rate due to respiratory failure. Effective treatment, however, is complicated by the fact that a definitive diagnosis often requires a lung biopsy.

“Unfortunately, many patients do not receive lung biopsies. As a result, about one-third of patients who come to our clinic have previously been misdiagnosed, and many have been treated with the wrong medications,” explained James Dauber, M.D., medical director of the University of Pittsburgh’s Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, and professor of medicine, division of pulmonary, allergy and critical care medicine...Read the full news release

This release also refers to another study offering additional potential hope for IPF patients. It goes on to say:

"Although there currently is no effective treatment for idiopathic pulmonary fibrosis, results of another study suggest help may soon be on the way. Dr. Kaminski and his colleagues reported in the Sept. 6 online edition of PLoS Medicine that idiopathic pulmonary fibrosis lung tissue samples display an “over-abundance” of a protein known as osteopontin, which other studies have implicated in the growth and progression of tumors. In further examining the potential role of osteopontin in idiopathic pulmonary fibrosis, Dr. Kaminski’s group found that it directly increases the proliferation and movement of fibroblasts, cells centrally involved in lung fibrosis"...
Full News Release

1 comment:

Latin's Lady said...

Video slots on the web has a fan club of there own, people just can’t get enough. Even when news slots are launched by the different software developers they get a standing ovation and are attacked with an intensity of a wolf mother protecting her cubs. It is like the New Years sale in Bond street where the entire population of crazy housewife’s fight over every garment and will draw blood if need be.

Lucky us the since the slots are online there is no such thing as a queue and you can play when you want. You don’t even have to get dressed.

Not that this has any relevance to who plays slots and who don’t. There is clearly according to the latest polls more women playing slots then men. Men seem to drift towards the poker and table games. But here is something us men have to watch out for, they are coming. And they are also coming in swarms.

And since we men can not do more then one thing at a time (at least that is what the women say) we are in trouble. Take Blackjack, they should be better at handling two and three hands then us. Texas Hold’em is up for grabs because of the pace and many factors in the game. So when you are playing against a women you might want to hold on to your chips (and maybe your hart as well) she could end up owning both of them. Women know we are simple beings, and do have this factor over us when playing face to face. All men are suckers to a nice smile, so in all fairness any poker game that has both men and women in it should be played online.

At least you will not be distracted by that nice perfume drifting in from the women next to you. It is so faint but a man has certain instincts and will try to get a good sniff. So leaning in (ever so careful) I still get booted from a game for trying to look at other peoples cards. And I had a straight lined up. Even the big smile I got from the women next to me did not really soften the blow of getting booted. At least the dealer understood me and just told me to take a break for a while. That is my 2 cents worth on the topic of women and gambling.

Signing off for now and heading towards the slots, someone told me there is a good chance of meeting women there. At least that is what they tell me on